|Year : 2016 | Volume
| Issue : 2 | Page : 69-75
Oxygen consumption testing and self-reported outcomes following limb salvage with tibiocalcaneal or tibio-talo-calcaneal fusion
S Robert Rozbruch1, Joshua R Buksbaum1, Austin T Fragomen1, Eugene W Borst1, Polly DeMille2
1 Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, USA
2 Sports Medicine Performance Center, Hospital for Special Surgery, New York, USA
|Date of Submission||02-Aug-2016|
|Date of Acceptance||07-Sep-2016|
|Date of Web Publication||16-Sep-2016|
S Robert Rozbruch
535 East 70th Street, NY, NY 10021
Source of Support: None, Conflict of Interest: None
Context: Little is known about the energy expenditure following limb salvage with tibiocalcaneal (TC) or tibio-talo-calcaneal (TTC) fusions and optimization of leg lengths. Studies have quantified the energy expenditures of amputees and tibiotalar fusion patients by measuring oxygen (O 2 ) consumption, but a similar study has yet to be performed on TC or TTC fusion patients. Since limb salvage with TC or TTC fusion is often considered an alternative treatment to a below the knee amputation (BKA), it will be useful to understand the relative energy expenditures of the two treatment groups.
Aims: To assess the energy expenditure and self-reported outcomes of patients who have undergone limb salvage with TC or TTC fusions, and to compare the O 2 consumption of TC and TTC fusion patients to those reported in the literature for patients who underwent BKAs.
Subjects and Methods: We gathered data on 12 TC and TTC fusion patients' O 2 consumptions at rest, their self-selected usual daily walking speed (UDWS), 80% of UDWS, 120% of UDWS, and a fixed speed of 2 miles/h (mph). Short form-36 (SF-36) and visual analog scores were also obtained.
Statistical Analysis: We calculated the averages and standard deviations of the O 2 consumption levels for our cohort of TC and TTC fusion patients.
Results: The TTC and TC patients overall averaged 10.4 mL O 2 /min/kg at an average UDWS of 1.9 mph. This O 2 consumption rate was 22% higher than normal. The outcome SF-36 scores
were 57 and 45 for the mental and physical components, respectively. The visual analog scale was 1.1.
Conclusion: Patients after TC and TTC fusions have minimal pain. SF-36 mental component scores were better than those of normal population, and physical component scores were minimally lower than the normal population. While O 2 consumptions was 22% above normal population, it was less than what has been reported in the literature for BKA patients.
Keywords: Ankle fusion, below knee amputation, metabolic efficiency, oxygen consumption, tibiocalcaneal fusion, tibiotalar fusion, tibio-talo-calcaneal fusion
|How to cite this article:|
Rozbruch S R, Buksbaum JR, Fragomen AT, Borst EW, DeMille P. Oxygen consumption testing and self-reported outcomes following limb salvage with tibiocalcaneal or tibio-talo-calcaneal fusion. J Limb Lengthen Reconstr 2016;2:69-75
|How to cite this URL:|
Rozbruch S R, Buksbaum JR, Fragomen AT, Borst EW, DeMille P. Oxygen consumption testing and self-reported outcomes following limb salvage with tibiocalcaneal or tibio-talo-calcaneal fusion. J Limb Lengthen Reconstr [serial online] 2016 [cited 2019 Oct 23];2:69-75. Available from: http://www.jlimblengthrecon.org/text.asp?2016/2/2/69/190706
| Introduction|| |
Tibiocalcaneal (TC) or tibio-talo-calcaneal (TTC) fusions are often used as limb salvage measures. TC and TTC fusions are effective procedures to treat end-stage arthritis, ankle infection, failed total ankle replacements, providing the patient with a stable and plantigrade foot [Figure 1].  Typically, fusion procedures are accompanied by future surgical interventions to address the resulting limb length discrepancy (LLD) or use of a shoe lift to optimize limb length. TC and TTC fusions can be achieved using multiple fixation techniques such as circular external fixation, plates, screws, and intramedullary nails. TC and TTC fusions can also be used to correct severe ankle and hindfoot malalignments.  The wide range of approaches and the ability to correct large deformities, treat infection, and reconstruct damaged ankle and hindfoot joints while relieving pain makes fusion procedures an extremely versatile option for limb salvage patients. However, fusion patients are still at large risk for infection and nonunion, and studies such as Kugan et al.  have reported rates as high as 40% for subsequent surgeries to address nonunion and infection, as well as 22% of fusion patients undergoing amputations. Even with a successful fusion, Kugan et al.  reported that 18% of patients had persistent pain. This along with gait abnormalities after TC or TTC fusion and limb salvage has led many clinicians to favor below the knee amputation (BKA).
|Figure 1: A 65-year-old female with extensive osteonecrosis of the talus. (a) AP X-ray of the right ankle. (b) Lateral X-ray of the right ankle. (c) Lateral X-ray showing a tibiocalcaneal fusion using circular external fixation after excision of the talus, 1 month after surgery. (d) Lateral X-ray following staged tibial lengthening and displaying the final distraction gap. The proximal ring was placed using LATN technique. (e) Anterior-posterior X-ray showing healed tibiocalcaneal fusion and lengthening site, with an intramedullary nail present as part of the LATN technique, 11 months after surgery. (f) Lateral X-ray. (g) Standing bipedal X-ray showing optimized leg lengths 11 months after tibiocalcaneal fusion and LATN. (h) Front view of the patient's ankles and legs, 2 years after tibiocalcaneal fusion and optimization of leg lengths. (i) Side view of the patient's ankles and legs, (j) Clinical photograph Rear view of the patient's ankles and legs. (k) Overall view of the patient's legs|
Click here to view
Metabolic data for BKAs have been studied to analyze the energy consumption of BKA patients. Colborne et al.,  Herbert et al.,  and Waters et al.  studied how differences in the level of amputation, type of prosthetic, and residual limb length were shown to impact the energy consumption and overall metabolic activity of patients. There have also been studies quantifying the oxygen (O 2 ) consumption of tibiotalar (TT) fusion patients; however, there are no data available on how efficiently TC and TTC fusion patients consume energy. Because of this, we cannot effectively compare the metabolic outcomes of our patients who undergo a limb salvage procedure to those who undergo a BKA.
In this study, we measure the relative energy expenditures of patients who have undergone limb salvage with TC or TTC fusions. By comparing our data on the O 2 consumption of TC and TTC fusion patients to the O 2 consumption levels of posttraumatic BKA patients sourced from published literature, we hope to add a new metric to the discussion of limb salvage versus amputation. The data of this study will aid patients and surgeons in their decision-making processes between electing for limb salvage TC or TTC fusions or opting to undergo a BKA.
| Subjects and Methods|| |
Twelve patients who were at least 1 year following limb salvage with TC or TTC fusions and optimization of leg lengths were included in the study. The average age was 55.4 years (range: 33-66), and there were 9 women and 3 men [Table 1]. Patients were treated with TC or TTC fusion for limb salvage using circular external fixation. LLD was addressed with either a shoe lift or tibia lengthening  [Table 1]. Shoe lifts were used based on patient comfort and ranged from complete correction of the deformity to 1 cm of shortening. LLD after tibia lengthening also ranged from 0 to 1 cm of shortening and was also based on patient comfort. There was no correlation between LLD and O 2 consumption data. The demographics including age, sex, etiology, and comorbidities are outlined [Table 1].
O 2 consumption testing was conducted using a metabolic measurement system (ParvoMedics TrueOne® 2400, Parvo, UT). Patients then selected their usual daily walking speed (UDWS) measured in miles per hour (mph). Four walking trials of 3-8 min durations were conducted. During each walking trial, patients walked until they attained a steady state heart rate (±5 heart beats/min) and O 2 consumption (±150 ml/min) for 3 consecutive min. Trials were conducted in a randomized order with gradual adjustment of speed between trials to serve as adjustment time. The four trial speeds were 80%, 100%, and 120% of their UDWS, and 2 mph. Steady state O 2 consumption (ml/min/kg) in each condition was compared to predicted values based on the American College for Sports Medicine metabolic equation for walking. Deviations from predicted values were reported for each condition. Patient self-reported short form-36 (SF-36) outcome scores were also collected and compared to normal population. Visual analog scores (VASs) were obtained after traversing stairs and scaled at 1-10. The VAS is a self-reported response scale used in questionnaires to measures patients' perception of their pain. It asks patients to draw a line between two points based on their current levels of pain and is used to measure subjective or intangible differences among patients' pain levels.
Studies in the literature were gathered from numerous peer-reviewed journal articles. We selected nine articles containing data on the O 2 consumption of amputees and compared each of those articles' data to our own data gathered on fusion patients' O 2 consumption. We also gathered data on O 2 consumption after simple TT ankle fusions, and we relied predominantly on Vanderpool et al.  and Waters et al.  because these studies provided the best comparison. For the BKA group, we focused on Waters et al.,  Molen,  Torburn et al.,  and Nielsen et al.,  due to their similar age ranges to our cohort of fusion patients. We selected these articles from online search databases using the search terms "amputations + O 2 consumption," as well as "ankle fusion + O 2 consumption."
| Results|| |
At the UDWS of 1.9 ± 0.4 mph, the O 2 consumption was 10.6 ± 1.9 ml/kg/min and this was 23.8% ±12.9% higher than normal. At 80% of UDWS of 1.5 ± 0.3 mph, the O 2 consumption was 9.3 ± 1.6 ml/kg/min and this was 24% ±13.5% higher than normal. At 120% of UDWS of 2.3 ± 0.5 mph, the O 2 consumption was 11.2 (±1.7) ml/kg/min and this was 22.5 (±13.6) % higher than normal. At a standardized 2 mph speed, O 2 consumption was 10.6 (±1.3) ml/kg/min, and this was 19.9 (±13.9) % higher than normal [Figure 2], [Figure 3] and [Table 2]. The fusion patients' SF-36 mental component score was 57 (±4), their physical component score was 45 (±13), and their VAS was 1.1 (±1.6). There was no correlation between LLD and O 2 consumption data.
|Figure 2: Average volume of oxygen consumed in fusion patients by velocity. This graph summarizes the results of our oxygen consumption trials on tibiocalcaneal and tibio-talo-calcaneal fusion patients. The average oxygen consumption across the 12 patients is displayed for each velocity|
Click here to view
|Figure 3: Volume of oxygen consumed by velocity by patient. This graph presents an additional summary of our oxygen consumption data, by showing each patient's oxygen consumption level at different speeds|
Click here to view
|Table 2: Summary of the O2 consumption results at each speed during the trial of our TC and TTC fusion patients presented with the percent above normal O2 consumption, and the standard deviation |
Click here to view
| Discussion|| |
Our patients who underwent TC or TTC fusions had minimal pain as illustrated by their low VAS of 1.1 (±1.6). Their self-reported mental component SF-36 score of 57 (±4) was above the normal average of 53 (±10). In addition, their physical component scores of 45 (±12) were only slightly below the normal average of 51 (±10).
After our analysis of the O 2 consumption of complex ankle fusion patients, we compared their O 2 levels to the O 2 consumption levels of BKA [Table 3] and TT fusion [Table 4] patients in the literature. We selected six papers on BKA patients to serve as references and discussed select data from these papers to create an effective comparison to our TTC or TC fusion patients. As mentioned above, some of the data from these papers were excluded due to differences in patient age and methods. Colborne et al.  served as an effective starting point for our comparison to BKAs and their overall fitness, as it analyzed the velocity and stride lengths of amputees. However, this study was not an effective comparison due to its focus on pediatric congenital amputees as opposed to older, traumatic amputees. Herbert et al.  also served as a background source, as it analyzed O 2 consumption levels in amputees, however, like Colborne et al.,  it focused on pediatric congenital amputees.
Our most relevant comparisons were from papers that focused on O 2 consumption in traumatic BKAs [Table 3]. Each of the following papers used similar methods to collect their O 2 consumption data. Waters et al.  analyzed the O 2 consumption of BKAs at two speeds: The patients unrestrained walking speed and their maximum possible speed. The study's cohort included 14 traumatic BKAs with an average age of 29, which is much younger than our cohort but more comparable than the above pediatric studies. Waters et al. reported that at an average speed of 2.65 mph, the traumatic amputees averaged 22.4 ml/kg/min (±4.3) of O 2 consumed. Nielsen et al.  analyzed the O 2 consumption of BKAs at many speeds: At the patient's self-selected velocity, as well as at 1, 1.5, 2, 2.5, 3, 3.5, and 4 mph. The 14 patients averaged 26.7 years of age. Nielsen et al.'s results highlight that BKAs using two different prostheses have elevated O 2 consumption levels at each velocity compared to the nonamputee cohort. Molen  conducted a much larger study, observing the O 2 consumption among 35 traumatic BKAs, averaging 36 years of age. Molen and his team focused on developing a regression model for O 2 consumption and reported that their amputee patients were able to exceed expectations and consumed comparable O 2 levels to normal patients. Finally, Torburn et al.  analyzed the energy expenditures of 9 traumatic BKAs whose average age was 50 years of age at their self-selected walking speeds. Torburn et al.'s study was designed to compare the efficiency of different prosthesis types, and her data can be used as a large-scale control for O 2 consumption in traumatic BKAs. The results in the Torburn et al. study were an average O 2 consumption levels of 17.72 ml of O 2 per/kg/min at an average velocity of 82.3 m/min or 3.07 mph [Table 3].
Overall, these six papers provide a summary of the relevant studies on below the knee amputees ability to walk, and how efficiently they consume O 2 and expend energy. Most importantly, Nielsen et al. and Torburn et al. display the O 2 consumption of traumatic amputees across many different speeds, as well as their self-selected walking speed. In addition, Molen provides information on how to model expected O 2 consumption data based on the BKAs personal information.
Overall, the O 2 consumption was lower in the current study compared to the studies on BKA patients although the walking speed was also lower in the current study.
For our analysis of TT fusion patients' O 2 consumption, we selected six papers as references and focused mainly on two of them. We selected four papers that discussed how TT fusions affect different aspects of the patient's general lower limb health. Coester et al.  analyzed how TT fusions affect the onset of arthritis in the talonavicular and calcaneocuboid joints, as well as in the knee. Kaufman et al.  briefly discussed how a simulated ankle fusion in a knee ankle foot orthotic (KAFO) affected O 2 consumption. However, this study was geared more toward analyzing the stability of the knee in a KAFO as opposed to quantifying an increase in O2 consumption. Finally, Piriou et al.  and Valderrabano et al.  set out to compare ankle replacements to TT fusions. Piriou et al.  compared the gaits of patients undergoing both procedures, while Valderrabano et al.  compared the patients' range of motion in the foot following both procedures.
We focused mainly on Waters et al.  and Vanderpool et al.'s  work, as their studies honed in on the O 2 consumption levels of TT fusion patients [Table 4]. Waters et al.  study focused on the effects of different fusion procedures on patients' O2 consumption and included a group of ten posttraumatic TT fusion patients, with an average age of 37 years old. These patients consumed 12.0 mL/min/kg of O 2 while walking at an average speed of 2.5 mph. Vanderpool et al.  took a different approach, comparing the effect of a simulated TT fusion on O 2 consumption. He analyzed six patients ranging from 22 to 40 years old, and their O 2 consumption levels while wearing an ankle brace compared to those of patients walking unrestricted. Vanderpool et al. found that the simulated fusion patients walked at 2.79 mph and consumed 16.0 mL/min/kg of O 2 . These two studies serve as an effective comparison to our own cohort, allowing us to compare the O 2 consumption levels of patients under different fusion procedures or conditions [Table 4]. Surprisingly, the O 2 consumption was higher in the TT fusions than in the current study.
Despite our ability to quantify and analyze the O 2 consumption of TC and TTC fusion patients, we faced numerous limitations over the course of our research. We had difficulty gathering a large cohort, and thus our sample size was limited to twelve patients. In addition, we did not have our own control group of BKA and TT fusion patients to analyze, which forced us to rely on literature review for data on these patients' O 2 consumption levels. Because of this, we paid close attention to selecting studies that most closely matched our patient group, to account for differences in age and cause of amputation patients relative to our fusion patients. This also prevented us from performing an exact comparison of O 2 consumption levels across different velocities, as we were forced to rely on whichever speeds were reported in those studies. In addition, the lack of recent papers discussing O 2 consumption in amputees forced us to use studies over 20 years old, which fail to account for the advances in surgical technique, postoperative care, and prosthetics.
We did not have VAS or SF-36 data before surgery, and we were not able to do a statistical comparison of our postoperative SF-36 scores to those of the normal population.
| Conclusion|| |
Following limb salvage TC or TTC fusion and limb length optimization surgery, the patients' overall energy expenditure as measured by O 2 consumption was 10 ml/kg/min which was 22% above normal. Our patients had minimal pain, and their mental component SF-36 scores were above the normal average, and their physical component scores were only slightly below the normal average. Our patients' O 2 consumption levels compare favorably to levels reported in patients following BKAs. Because of this, we are inclined to believe that undergoing a limb salvage procedure, such as a TTC or TC fusion, has a favorable effect on metabolic efficiency compared to those who undergo a BKA.
Our clinical experience treating patients with TC and TTC fusion limb salvage along with optimization of leg lengths has been very positive, and our patients have been happy to have been able to save their limb. This study supports that this limb salvage undertaking was not at the cost of poor function, excessive energy expenditure, or pain. In the future, the addition of a control group of BKA patients and the use of a more extensive lower extremity outcome score would allow us to make more conclusive statements on patient satisfaction and function.
Financial support and sponsorship
The study was funded by Hospital for Special Surgery.
Conflicts of interest
There are no conflicts of interest.
| References|| |
Kugan R, Aslam N, Bose D, McNally MA. Outcome of arthrodesis of the hindfoot as a salvage procedure for complex ankle pathology using the Ilizarov technique. Bone Joint J 2013;95-B: 371-7.
Asomugha EU, Den Hartog BD, Junko JT, Alexander IJ. Tibiotalocalcaneal fusion for severe deformity and bone loss. J Am Acad Orthop Surg 2016;24:125-34.
Colborne GR, Naumann S, Longmuir PE, Berbrayer D. Analysis of mechanical and metabolic factors in the gait of congenital below knee amputees. A comparison of the SACH and Seattle feet. Am J Phys Med Rehabil 1992;71:272-8.
Herbert LM, Engsberg JR, Tedford KG, Grimston SK. A comparison of oxygen consumption during walking between children with and without below-knee amputations. Phys Ther 1994;74:943-50.
Waters RL, Perry J, Antonelli D, Hislop H. Energy cost of walking of amputees: The influence of level of amputation. J Bone Joint Surg Am 1976;58:42-6.
Rozbruch SR, Kleinman D, Fragomen AT, Ilizarov S. Limb lengthening and then insertion of an intramedullary nail: A case-matched comparison. Clin Orthop Relat Res 2008;466:2923-32.
Vanderpool MT, Collins SH, Kuo AD. Ankle fixation need not increase the energetic cost of human walking. Gait Posture 2008;28:427-33.
Waters RL, Barnes G, Husserl T, Silver L, Liss R. Comparable energy expenditure after arthrodesis of the hip and ankle. J Bone Joint Surg Am 1988;70:1032-7.
Molen NH. Energy-speed relation of below-knee amputees walking on a motor-driven treadmill. Int Z Angew Physiol 1973;31:173-85.
Torburn L, Powers CM, Guiterrez R, Perry J. Energy expenditure during ambulation in dysvascular and traumatic below-knee amputees: A comparison of five prosthetic feet. J Rehabil Res Dev 1995;32:111-9.
Nielsen DH, Shurr DG, Golden JC, Meier K. Comparison of energy cost and gait efficiency during ambulation in below-knee amputees using different prosthetic feet: A preliminary report. J Prosthet Orthot 1988;1:24-31.
Coester LM, Saltzman CL, Leupold J, Pontarelli W. Long-term results following ankle arthrodesis for post-traumatic arthritis. J Bone Joint Surg Am 2001;83-A: 219-28.
Kaufman KR, Irby SE, Mathewson JW, Wirta RW, Sutherland DH. Energy-efficient knee-ankle- foot orthosis: A case study. J Prosthet Orthot 1996;8:79-85.
Piriou P, Culpan P, Mullins M, Cardon JN, Pozzi D, Judet T. Ankle replacement versus arthrodesis: A comparative gait analysis study. Foot Ankle Int 2008;29:3-9.
Valderrabano V, Hintermann B, Nigg BM, Stefanyshyn D, Stergiou P. Kinematic changes after fusion and total replacement of the ankle: Part 1: Range of motion. Foot Ankle Int 2003;24:881-7.
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2], [Table 3], [Table 4]